Abstract: Objective To explore the influences of thyroid associated ophthalmopathy (TAO) on the accommodative function of human eye. Design Prosprective case series. Participants 25 patients with TAO and 20 age and refraction matched healthy controls. The average age of the patients was 31.0±6.2 years old (18~40 years). Methods Direct refraction and subjective accommodative amplitude test were performed for all the participants. Objective measurement of accommodative function was examined using the Nidek AA-1 accommodative analyzer. Main Outcome Measures Accommodative amplitude, accommodative response. Results In the subjective accommodative amplitude test, the accommodation amplitude of TAO patients (+5.42±1.97 D) was lower than that of the controls (+6.54±1.66 D) (t=-2.88，P=0.005). In the objective accommodative function test, accommodative dysfunction happened in 17 cases (68%), including 11 cases (44%) with accommodative lag; 4 cases (16%) with accommodative lag combined with accommodative strain, and 3 cases (8%) with accommodative strain. Conclusion TAO can cause accommodative dysfunction, in which accommodative lag is most common. (Ophthalmol CHN, 2015, 24: 119-122)

Key words: thyroid associated ophthalmopathy, ciliary muscle, accommodative function